Biocatalysis & Green Chemistry Lab

139. Yi, J., Goh, N.J.J. & Li, Z.* Green and Enantioselective Synthesis via Cascade Biotransformations: From Simple Racemic Substrates to High-Value Chiral Chemicals. Chemistry - An Asian Journal, 2024, e202400565, doi: 10.1002/asia.202400565. Link

138. Huang, L.*, Li, X, & Li, Z. Immobilization of enzymes on polymers with upper critical solution temperature: promising engineering of enzymes for biocatalysis. Reaction Chemistry & Engineering, 2024, 9, 1605-1628, doi: 10.1039/d3re00685a. Link

137. Khanppnavar, B., Choo, J.P.S., Hagedoorn, P., Smolentsev, G., Štefanić, S., Kumaran, S., Tischler, D., Winkler, F.K., & Korkhov, V.M.*, Li, Z.*, Kammerer, R. A.*, Li, X.* Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase. Nature Chemistry, 2024, doi: 10.1038/s41557-024-01523-y. Link

136. See, W.W.L., Choo, J.P.S., Du, L., & Li, Z.* Engineering Styrene Oxide Isomerase Towards Enhanced Chemoenzymatic Synthesis of (S)-Flurbiprofen. Advanced Synthesis & Catalysis, 2024, doi: 10.1002/adsc.202400325. Link

135. See, W.W.L., & Li, Z.* Enantiodivergent Functionalization of Aryl Alkenes into Diverse Biarylalkanoic Acids by Integrating Biocatalytic Cascades with Chemocatalysis. ACS Catalysis, 2023, 13, 13215–13224, doi: 10.1021/acscatal.3c03456. Link

134. Jung, D., & Li, Z.* Highly active and recyclable immobilized multiple enzymes for one-pot enantioselective cascade reactions: Synthesis of (R)- and (S)-α-amino acids from racemic α-hydroxy acids. Appl. Catal. B., 2024, 134, 123313, doi: 10.1016/j.apcatb.2023.123313. Link

133. Choo, J.P.S., Sirota, F. L., See, W.W.L, Eisenhaber, B., & Li, Z.* Engineering of Styrene Oxide Isomerase for Enhanced Production of 2-Arylpropionaldehydes: Chemoenzymatic Synthesis of (S)-Profens. ACS Catalysis, 2023, 13, 11268-11276, doi: 10.1021/acscatal.3c02777. Link

132. See, W.W.L., & Li, Z.* Styrene Oxide Isomerase-Catalyzed Meinwald Rearrangement in Cascade Biotransformations: Synthesis of Chiral and/or Natural Chemicals. Chemistry - A European Journal, 2023, e202300102, doi: 10.1002/chem.202300102. Link

131. Kua, G.K.B., Nguyen, G.K.T., & Li, Z.* Enzyme Engineering for High-Yielding Amide Formation: Lipase Catalyzed Synthesis of N-Acyl Glycine in Aqueous Media. Angewandte Chemie, 2023, e202217878, doi: 10.1002/anie.202217878. Link

130. Jung, D., Li, X., & Li, Z.* Engineering of Hydroxymandelate Oxidase and Cascade Reactions for High-Yielding Conversion of Racemic Mandelic Acids to Phenylglyoxylic Acids and (R)- and (S)-Phenylglycines. ACS Catalysis, 2023, 13, 1522-1532, doi: 10.1021/acscatal.2c05596. Link

129. See, W.W.L., Li, X., & Li, Z.* Biocatalytic Cascade Conversion of Racemic Epoxides to (S)-2-Arylpropionic Acids, (R)- and (S)-2-Arylpropyl Amines. Advanced Synthesis & Catalysis, 2023, 365, 68-77, doi: 10.1002/adsc.202201061. Link

128. Yi, J., & Li, Z.* Artificial multi-enzyme cascades for natural product synthesis. Current Opinion in Biotechnology, 2022, 78: 102831, doi: 10.1016/j.copbio.2022.102831. Link

127. Yi, J., Wang, Z., & Li, Z.* Cascade Biotransformations for Enantioconvergent Conversion of Racemic Styrene Oxides to (R)-Mandelic Acids. ACS Catalysis, 2022, 12, 13697−13702, doi: 10.1021/acscatal.2c04472. Link

126. See, W.W.L., Choo, J.P.S., Jung, D., & Li, Z.* Recent developments in oxidative biocatalytic cascades. Current Opinion in Green and Sustainable Chemistry, 2022, 38: 100700, doi: 10.1016/j.cogsc.2022.100700. Link

125. Wang, Z., Li, X., & Li, Z.* Engineering of Cascade Reactions and Alditol Oxidase for High-Yielding Synthesis of (R)-Phenylethanolamine from Styrene, l-Phenylalanine, Glycerol or Glucose. ChemCatChem, 2022, e202200418, doi: 10.1002/cctc.202200418. Link

124. Xin, R., See, W.W.L., Li, X., Yun, H., & Li, Z.* Enzyme-Catalyzed Meinwald Rearrangement with an Unusual Regioselective and Stereospecific 1,2-Methyl Shift. Angewandte Chemie, 2022, 61, e202204889, doi: 10.1002/anie.202204889. Link

123. Li, R., Tian, K., Li, X., Gaikaiwari, A.R., & Li, Z.* Engineering P450 Monooxygenases for Highly Regioselective and Active p-Hydroxylation of m-Alkylphenols. ACS Catalysis, 2022, 12, 5939–5948, doi: 10.1021/acscatal.1c06011. Link

122. Choo, J.P.S., & Li, Z.* Styrene Oxide Isomerase Catalyzed Meinwald Rearrangement Reaction: Discovery and Application in Single-Step and One-Pot Cascade Reactions. Org. Process Res. Dev., 2022, 26, 7, 1960-1970, doi: 10.1021/acs.oprd.1c00473. Link

121. Sekar, B.S., Li, X. & Li, Z.* Bioproduction of Natural Phenethyl Acetate, Phenylacetic Acid, Ethyl Phenylacetate, and Phenethyl Phenylacetate from Renewable Feedstock. ChemSusChem, 2022, e202102645, doi: 10.1002/cssc.202102645. Link

120. Lukito, B.R., Wang, Z., Sekar, B.S., & Li, Z.* Production of (R)-mandelic acid from styrene, L-phenylalanine, glycerol, or glucose via cascade biotransformations. Bioresources and Bioprocessing, 2021, 8: 22, doi: 10.1186/s40643-021-00374-6. Link

119. Choo, J.P.S., Kammerer, R., Li, X., & Li, Z.* High-level production of phenylacetaldehyde using fusion-tagged styrene oxide isomerase. Advanced Synthesis & Catalysis, 2021, 363: 1714-1721, doi: 10.1002/adsc.202001500. Link

118. Wang, Z., Sekar B.S., & Li, Z.* Recent advances in artificial enzyme cascades for the production of value-added chemicals. Bioresource Technology, 2021, 323: 124551, doi: 10.1016/j.biortech.2020.124551. Link

117. Sekar, B.S., Mao J., Lukito B.R., Wang, Z., & Li, Z.* Bioproduction of enantiopure (R)- and (S)-2-phenylglycinols from styrenes and renewable feedstocks. Advanced Synthesis & Catalysis, 2021, 363: 1892-1903, doi: 10.1002/adsc.202001322. Selected as Very Important Paper and published in journal's front cover. Link

116. Tian, K., & Li, Z.* A simple biosystem for the high-yielding cascade conversion of racemic alcohols to enantiopure amines. Angewandte Chemie, 2020, 59: 21745-21751, doi: 10.1002/anie.202009733. Link

115. Zhou, Y., Sekar, B. S., Wu, S., & Li, Z.* Benzoic acid production via cascade biotransformation and coupled fermentation-biotransformation. Biotechnology and Bioengineering, 2020, 117: 2340-2350, doi: 10.1002/bit.27366. Link

114. Yuan J., Lukito B.R., & Li, Z.* De novo biosynthesis of (S)- and (R)-phenylethanediol in yeast via artificial enzyme cascades. ACS Synthetic Biology, 2019, 8: 1801-1808, doi: 10.1021/acssynbio.9b00123. Link

113. Sekar B.S., Lukito B.R., & Li, Z.* Production of natural 2-phenylethanol from glucose or glycerol with coupled Escherichia coli strains expressing L-phenylalanine biosynthesis pathway and artificial biocascades. ACS Sustainable Chemistry & Engineering, 2019, 14: 12231-12239, doi: 10.1021/acssuschemeng.9b01569. Link

112. Liu, J., & Li, Z.* Enhancing cofactor recycling in the bioconversion of racemic alcohols to chiral amines with alcohol dehydrogenase and amine dehydrogenase by coupling cells and cell-free system. Biotechnology and Bioengineering, 2019, 116: 536-542, doi: 10.1002/bit.26896. Link

111. Lukito B.R., Wu S., Saw H.J.J., & Li, Z.* One-pot production of natural 2-phenylethanol from L-phenylalanine via cascade biotransformations. ChemCatChem, 2019, 11: 831-840, doi: 10.1002/cctc.201801613. Link

110. Wu S., Zhou Y., & Li, Z.* Biocatalytic selective functionalisation of alkenes: Via single-step and one-pot multi-step reactions. Chemical Communications, 2019, 55: 883-896, doi: 10.1039/C8CC07828A. Link

109. Lukito B.R., Sekar B.S., Wu S., & Li, Z.* Whole cell-based cascade biotransformation for the production of (S)-mandelic acid from styrene, L-phenylalanine, glucose, or glycerol. Advanced Synthesis & Catalysis, 2019, 361: 3560-3568, doi: 10.1002/adsc.201900373. Link

108. Cui H.-B., Xie L.-Z., Wan N.-W., He Q., Li, Z., Chen Y.-Z.* Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons. Green Chemistry, 2019, 21: 4324-4328, doi: 10.1039/C9GC01802F. Link

107. Zeng, S.,Liu, J., Anankanbil, S., Chen, M., Guo, Z., Adams, J.P., Snajdrova, R.& Li, Z.* Amide synthesis via aminolysis of ester or acid with an intracellular lipase. ACS Catalysis, 2018, 8: 8856-8865, doi: 10.1021/acscatal.8b02713. Link

106. Vahidi, A. K., Wang, Z., & Li, Z.* Facile synthesis of S-substituted L-cysteines with nano-sized immobilized O-acetylserine sulfhydrylase. ChemCatChem, 2018, 10: 3671-3674. Link

105. Zhou, Y., Wu, S., Mao, J., & Li, Z.* Bioproduction of benzylamine from renewable feedstocks via a nine-step artificial enzyme cascade and engineered metabolic pathways. ChemSusChem, 2018, 11: 2221-2228. Link

104. Liu, J., Wu, S., & Li, Z.* Recent advances in enzymatic oxidation of alcohols. Current Opinion in Chemical Biology, 2018, 43: 77-86. Link

103. Wu, S., & Li, Z.* Whole-cell cascade biotransformations for one-pot multistep organic synthesis. ChemCatChem, 2018, 10: 2164-2178. Link

102. Zhou, Y., Wu, S., & Li, Z.* One-pot enantioselective synthesis of D-phenylglycines from racemic mandelic acids, styrenes, or biobased L-phenylalanine via cascade biocatalysis. Advanced Synthesis & Catalysis, 2017, 359, 4305-4316. Selected as Very Important Paper and highlighted at the journal's front cover. Link

101. Tian, K., Tai, K., Chua, B.J.W., & Li, Z.* Directed evolution of Thermomyces lanuginosus lipase to enhance methanol tolerance for efficient production of biodiesel from waste grease. Bioresource Technology, 2017, 245, part B, 1491-1497. Link

100. Wu, S., Liu, J., & Li, Z.* Biocatalytic formal anti-Markovnikov hydroamination and hydration of aryl alkenes. ACS Catalysis, 2017, 7, 5225-5233. Link

99. Wu, S., Zhou, Y., Seet, D., & Li, Z.* Regio- and stereoselective oxidation of styrene derivatives to arylalkanoic acids via one-pot cascade biotransformations. Advanced Synthesis & Catalysis, 2017, 359, 2132-2141.Selected as Very Important Paper. Link

98. Liu, J. Pang, B. Q. W., Adams, J. P., Snajdrova, R., & Li, Z.* Coupled Immobilized Amine Dehydrogenase and Glucose Dehydrogenase for Asymmetric Synthesis of Amines by Reductive Amination with Cofactor Recycling. ChemCatChem, 2017, 9, 425-431. Link

97. Gao, P., Wu, S., Praveen, P., Loh, K.-C., & Li, Z.* Enhancing productivity for cascade biotransformation of styrene to (S)-vicinal diol with biphasic system in hollow fiber membrane bioreactor. Applied Microbiology and Biotechnology, 2017, 101, 1857-1868. Link

96. Tian, K., & Li, Z.* High-yielding, one-pot, and green production of biodiesel from waste grease using wet cells of a recombinant Escherichia coli strain as catalyst. Biochemical Engineering Journal, 2016, 115, 30-37. Link

95. Wu, S., Liu, J., & Li, Z.* Organic Synthesis via Oxidative Cascade Biocatalysis. Synlett, 2016, 27, 2644-2658. Link

94. Zhou, Y., Wu, S., & Li, Z.* Cascade Biocatalysis for Sustainable Asymmetric Synthesis: From Biobased l-Phenylalanine to High-Value Chiral Chemicals. Angewandte Chemie International Edition, 2016, 55, 11647-11650. Link

93. Wu, S., Zhou, Y., Wang, T. W., Too, H. P., Wang, D. I. C., & Li, Z.* Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis. Nature Communications, 2016, 7, 11917. Link

92. Vahidi, A. K., Wang, Z., Wong, W., & Li, Z.* Immobilization of O-acetylserine sulfhydrylase as highly active and recyclable nanobiocatalyst: efficient synthesis of b-pyrazol-1-yl-L-alanine. Catalysis Science & Technology, 2016, 6, 6286-6293. Link

91. Liu, J., & Li, Z.* Cascade biotransformations via enantioselective reduction, oxidation, and hydrolysis: preparation of (R)-d-lactone from 2-alkylidenecyclopentanones. in Practical Methods for Biocatalysis and Biotransformations 3., Eds., Peter W. Sutton, Wolfgang Kroutil. John Wiley & Sons, 2016, 230-232

90. Vahidi, A. K., Yang, Y., Ngo, T.P. N., & Li, Z.* Simple and efficient immobilization of extracellular his-tagged enzyme directly from cell culture supernatant as active and recyclable nanobiocatalyst: high-performance production of biodiesel from waste grease. ACS Catalysis, 2015, 5, 3157-3161. Link

89. Yang, Y., & Li, Z.* Evolving P450pyr monooxygenase for regio- and stereoselective hydroxylations. Chimia, 2015, 69, 136-141. Link

88. Li, A., & Li, Z.* Asymmetric synthesis of enantiopure epoxideds using monooxgenases. in Science of Synthesis: Biocatalysis in Organic Synthesis 2. ed, Faber, K., Fessner, W.-D., Turner, N.J. Thieme, Stuttgart, Germany, 2015

87. Huang, R., Wu, M., Goldman, M. J., & Li, Z.* Encapsulation of enzyme via one-step template-free formation of stable organic-inorganic capsules: a simple and efficient method for immobilizing enzyme with high activity and recyclability. Biotechnology and Bioengineering, 2015, 112, 1092-1101. Link

86. Ye, L. J., Toh, H. H., Yang, Y., Adams, J. P., Snajdrova, R., & Li, Z.* Engineering of Amine Dehydrogenase for Asymmetric Reductive Amination of Ketone by Evolving Rhodococcus Phenylalanine Dehydrogenase. ACS Catalysis, 2015, 5, 1119-1122. Link

85. Yang, Y., Chi, Y. T., Toh, H. H., & Li, Z.* Evolving P450pyr monooxygenase for highly regioselective terminal hydroxylation of n-butanol to 1,4-butanediol. Chemical Communications, 2015, 51, 514-517. Link

84. Limadinata, P. A., Li, A., & Li, Z.* Temperature-responsive nanobiocatalysts with an upper critical solution temperature for high performance biotransformation and easy catalyst recycling: efficient hydrolysis of cellulose to glucose. Green Chemistry, 2015, 17, 1194-1203. Link

83. Zhang, J., Wu, S., Wu, J., & Li, Z.* Enantioselective Cascade Biocatalysis via Epoxide Hydrolysis and Alcohol Oxidation: One-Pot Synthesis of (R)-a-Hydroxy Ketones from Meso- or Racemic Epoxides. ACS Catalysis, 2015, 5, 51-58. Link

82. Chen, Y.*, Zhuo, J., Zheng, D., Tian, S. & Li, Z. Stereoselective oxidation of sulfides to optically active sulfoxides with resting cells of Pseudomonas monteilii CCTCC M2013683. Journal of Molecular Catalysis B: Enzymatic, 2014, 106, 100-104. Link

81. Gao, P., Li, A., Lee, H. H., Wang, D. I. C., & Li, Z.* Enhancing enantioselectivity and productivity of P450-catalyzed asymmetric sulfoxidation with an aqueous/ionic liquid biphasic system. ACS Catalysis, 2014, 4, 3763-3771. Link

80. Zhang, D., Ong, Y. L., Li, Z.*, & Wu, J. C.* Optimization of two-step acid-catalyzed hydrolysis of oil palm empty fruit bunch for high sugar concentration in hydrolysate. International Journal of Chemical Engineering, 2014, doi:10.1155/2014/954632. Link

79. Liu, J., Wu, J. C., & Li, Z.* Enoyl acyl carrier protein reductase (FabI) catalyzed asymmetric reduction of C-C double bond of a,b-unsaturated ketones: preparation of (R)-2-alkyl-cyclopentanones. Chemical Communications, 2014, 50, 9729-9732. Link

78. Li, A., Wu, S., Adams, J. P., Snajdrova, R., & Li, Z.* Asymmetric epoxidation of alkene and benzylic hydroxylation with P450tol monooxygenase from Rhodococcus coprophilus TC-2. Chemical Communications, 2014, 50, 8771-8774. Link Highlighted in Synfact, 2014, 10, 1097.

77. Yang, Y., Liu, J., & Li, Z.* Engineering of P450pyr Hydroxylase for the Highly Regio- and Enantioselective Subterminal Hydroxylation of Alkanes. Angewandte Chemie International Edition, 2014, 53, 3120-3124. Selected as Very Important Paper, and highlighted at the back cover. Link

76. Wu, S., Chen, Y., Xu, Y., Li, A., Xu, Q., Glieder, A., & Li, Z.* Enantioselective trans-Dihydroxylation of Aryl Olefins by Cascade Biocatalysis with Recombinant E. coli Co-Expressing Monooxygenase and Epoxide Hydrolase. ACS Catalysis, 2014, 4, 409-420. Link Selected as ACS Editors' Choice (Jan 06 2014), highlighted in Synfact, 2014, 10, 0316, featured by Chemical & Engineering News C&EN, 2014, 92, 8. Link to the News

75. Zillillah, Ngu, T. A., & Li, Z.* Phosphotungstic acid-functionalized magnetic nanoparticles as an efficient and recyclable catalyst for the one-pot production of biodiesel from grease via esterification and transesterification. Green Chemistry. 2014, 16, 1202-1210. Link

74. Huang, R., Wu, S., Li, A., & Li, Z.* Integrating interfacial self-assembly and electrostatic complexation at an aqueous interface for capsule synthesis and enzyme immobilization. Journal of Materials Chemistry A, 2014, 2, 1672-1676. Link

73. Ye, L., Hudari, M. S. B., Li, Z.*, & Wu, J. C.* Simultaneous detoxification, saccharification and co-fermentation of oil palm empty fruit bunch hydrolysate for l-lactic acid production by Bacillus coagulans JI12. Biochemical Engineering Journal, 2014, 83, 16-21. Link

72. Li, A., Liu, J., Pham, S. Q., & Li, Z.* Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivity. Chemical Communications, 2013, 49, 11572-11574. Link

71. Zhang, J., Xu, T., & Li, Z.* Enantioselective Biooxidation of Racemic trans-Cyclic Vicinal Diols: One-Pot Synthesis of Both Enantiopure (S, S)-Cyclic Vicinal Diols and (R)-a-Hydroxy Ketones. Advanced Synthesis & Catalysis, 2013, 355, 3147-3153. Link

70. Brooks, S. J., Nikodinovic, J., Martin, L., Doyle, E. M., O'Sullivan, T., Guiry, P. J., Coulombel, L., Li, Z., & O'Connor, K. E.* Production of a chiral alcohol, 1-(3, 4-dihydroxyphenyl) ethanol, by mushroom tyrosinase. Biotechnology Letters, 2013, 35, 779-783. Link

69. Pham, S. Q., Gao, P., & Li, Z.* Engineering of recombinant E. coli cells co-expressing P450pyrTM monooxygenase and glucose dehydrogenase for highly regio-and stereoselective hydroxylation of alicycles with cofactor recycling. Biotechnology and Bioengineering, 2013, 110, 363-373. Link

68. Liu, J., & Li, Z.* Cascade Biotransformations via Enantioselective Reduction, Oxidation, and Hydrolysis: Preparation of (R)-Lactones from 2-Alkylidenecyclopentanones. ACS Catalysis, 2013, 3, 908-911. Link

67. Wu, S., Li, A., Chin, Y. S., & Li, Z.* Enantioselective Hydrolysis of Racemic and Meso-Epoxides with Recombinant Escherichia coli Expressing Epoxide Hydrolase from Sphingomonas sp. HXN-200: Preparation of Epoxides and Vicinal Diols in High ee and High Concentration. ACS Catalysis, 2013, 3, 752-759. Link

66. Ngo, T. P., Li, A., Tiew, K. W., & Li, Z.* Efficient transformation of grease to biodiesel using highly active and easily recyclable magnetic nanobiocatalyst aggregates. Bioresource Technology, 2013, 145, 233-239. Link

65. Ye, L., Hudari, M. S. B., Zhou, X., Zhang, D., Li, Z.*, & Wu, J. C.* Conversion of acid hydrolysate of oil palm empty fruit bunch to L-lactic acid by newly isolated Bacillus coagulans JI12. Applied Microbiology and Biotechnology, 2013, 97, 4831-4838. Link

64. Ye, L., Zhao, H., Li, Z.*, & Wu, J. C.* Improved acid tolerance of Lactobacillus pentosus by error-prone whole genome amplification. Bioresource Technology, 2013, 135, 459-463. Link

63. Ye, L., Zhou, X., Hudari, M. S. B., Li, Z.*, & Wu, J. C.* Highly efficient production of l-lactic acid from xylose by newly isolated Bacillus coagulans C106. Bioresource Technology, 2013, 132, 38-44. Link

62 Zhang, D., Ong, Y. L., Li, Z.*, & Wu, J. C.* Biological detoxification of furfural and 5-hydroxyl methyl furfural in hydrolysate of oil palm empty fruit bunch by Enterobacter sp. FDS8. Biochemical Engineering Journal, 2013, 72, 77-82. Link

61. Zillillah, Tan, G., & Li, Z.* Highly active, stable, and recyclable magnetic nano-size solid acid catalysts: efficient esterification of free fatty acid in grease to produce biodiesel. Green Chemistry, 2012, 14, 3077-3086. Link

60. Chen, H., Ma, X.*, Li, Z., Shi, Q., Zheng, W., Liu, Y. and Wang, P. Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth. Biomedicine & Pharmacotherapy, 2012, 66, 334-338. Link

59. Ngo, T. P., Zhang, W., Wang, W., & Li, Z.* Reversible clustering of magnetic nanobiocatalysts for high-performance biocatalysis and easy catalyst recycling. Chemical Communications, 2012, 48, 4585-4587. Link

58. Pham, S. Q., Pompidor, G., Liu, J., Li, X. D., & Li, Z.* Evolving P450pyr hydroxylase for highly enantioselective hydroxylation at non-activated carbon atom. Chemical Communications, 2012, 48, 4618-4620. Link

57. Zhang, D., Ong, Y. L., Li, Z.*, & Wu, J. C.* Optimization of dilute acid-catalyzed hydrolysis of oil palm empty fruit bunch for high yield production of xylose. Chemical Engineering Journal, 2012, 181, 636-642. Link

56. Li, A., Ngo, T. P., Yan, J., Tian, K., & Li, Z.* Whole-cell based solvent-free system for one-pot production of biodiesel from waste grease. Bioresource Technology, 2012, 114, 725-729. Link

55. Yan, J., Li, A., Xu, Y., Ngo, T. P., Phua, S., & Li, Z.* Efficient production of biodiesel from waste grease: One-pot esterification and transesterification with tandem lipases. Bioresource Technology, 2012, 123, 332-337. Link

54. Xue, L., Dai, S., & Li, Z.* Synthesis and characterization of elastic star shape-memory polymers as self-expandable drug-eluting stents. Journal of Materials Chemistry, 2012, 22, 7403-7411. Link

53. Li, K., Ding, D., Huo, D., Pu, K. Y., Thao, N. N. P., Hu, Y., Li, Z., & Liu, B.* Conjugated Polymer Based Nanoparticles as Dual-Modal Probes for Targeted In Vivo Fluorescence and Magnetic Resonance Imaging. Advanced Functional Materials, 2012, 22, 3107-3115. Link

52. Xu, Y., Li, A., Jia, X., & Li, Z.* Asymmetric trans-dihydroxylation of cyclic olefins by enzymatic or chemo-enzymatic sequential epoxidation and hydrolysis in one-pot. Green Chemistry, 2011, 13, 2452-2458. Link

51. Zhang, W., Tang, W. L., Wang, D. I., & Li, Z.* Concurrent oxidations with tandem biocatalysts in one pot: green, selective and clean oxidations of methylene groups to ketones. Chemical Communications, 2011, 47, 3284-3286. Link

50. Wang, W., Wang, D. I., & Li, Z.* Facile fabrication of recyclable and active nanobiocatalyst: purification and immobilization of enzyme in one pot with Ni-NTA functionalized magnetic nanoparticle. Chemical Communications, 2011, 47, 8115-8117. Link

49. Dai, S., Xue, L., & Li, Z.* Enzymatic Ring-Opening Polymerization of Trimethylene Carbonate with Macrodiol: Synthesis of Block Poly (ester-co-carbonate) for Biomaterial Preparation. ACS Catalysis, 2011, 1, 1421-1429. Link

48. Jia, X., Xu, Y., & Li, Z.* Regio-and stereoselective concurrent oxidations with whole cell biocatalyst: simple and green syntheses of enantiopure 1, 2-diols via oxidative kinetic resolution. ACS Catalysis, 2011, 1, 591-596. Link

47. Tang, W. L., Li, Z.*, & Zhao, H.* Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution. Chemical Communication, 2010, 46, 5461-5463. Link

46. Zhang, W., Tang, W. L., Wang, Z., & Li, Z.* Regio-and Stereoselective Biohydroxylations with a Recombinant Escherichia coli Expressing P450pyr Monooxygenase of Sphingomonas Sp. HXN-200. Advanced Synthesis & Catalysis, 2010, 352, 3380-3390. Link

45. Dai, S., Wu, J., Wang, Z., Chen, Y., & Li, Z.* Highly chemo-and regio-selective hydroxylations of o-and m-substituted toluenes to benzyl alcohols with Cellulosimicrobium cellulans EB-8-4. Tetrahedron, 2010, 66, 6919-6923. Link

44. Chen, Y., Tang, W. L., Mou, J., & Li, Z.* High-Throughput Method for Determining the Enantioselectivity of Enzyme-Catalyzed Hydroxylations Based on Mass Spectrometry. Angewandte Chemie International Edition, 2010, 49, 5278-5283. Link

43. Xue, L., Dai, S., & Li, Z.* Biodegradable shape-memory block co-polymers for fast self-expandable stents. Biomaterials, 2010, 31, 8132-8140. Link

42. Xu, Y., Jia, X., Panke, S., & Li, Z.* Asymmetric dihydroxylation of aryl olefins by sequential enantioselective epoxidation and regioselective hydrolysis with tandem biocatalysts. Chemical Communications, 2009, (12), 1481-1483. Selected as a Hot Article in Chem. Commun., Link

41. Lie, F., Chen, Y., Wang, Z., & Li, Z.* Enantioselective benzylic hydroxylation of indan and tetralin with Pseudomonas monteilii TA-5. Tetrahedron: Asymmetry, 2009, 20, 1206-1211. Link

40. Chen, Y., Lie, F., & Li, Z.* Enantioselective Benzylic Hydroxylation with Pseudomonas monteilii TA-5: A Simple Method for the Syntheses of (R)-Benzylic Alcohols Containing Reactive Functional Groups. Advanced Synthesis & Catalysis, 2009, 351, 2107-2112. Highlighted in Synfacts, 2009, 1401. Link

39. Wang, Z., Lie, F., Lim, E., Li, K., & Li, Z.* Regio-and Stereoselective Allylic Hydroxylation of D-Limonene to (+)-trans-Carveol with Cellulosimicrobium cellulans EB-8-4. Advanced Synthesis & Catalysis, 2009, 351, 1849-1856. Link

38. Dai, S., Xue, L., Zinn, M., & Li, Z.* Enzyme-catalyzed polycondensation of polyester macrodiols with divinyl adipate: A green method for the preparation of thermoplastic block copolyesters. Biomacromolecules, 2009, 10, 3176-3181. Link

37. Zhang, W., O'Connor, K., Wang, D. I., & Li, Z.* Bioreduction with efficient recycling of NADPH by coupled permeabilized microorganisms. Applied and Environmental Microbiology, 2009, 75, 687-694. Selected as one of the six best ASM journal articles for March 2009, Link

36. Binazadeh, M., Karimi, I. A., & Li, Z.* Fast biodegradation of long chain n-alkanes and crude oil at high concentrations with Rhodococcus sp. Moj-3449. Enzyme and Microbial Technology, 2009, 45, 195-202. Link

35. Xue, L., Dai, S., & Li, Z.* Synthesis and Characterization of Three-Arm Poly (caprolactone)-Based Poly (ester- urethanes) with Shape-Memory Effect at Body Temperature. Macromolecules, 2009, 42, 964-972. Link

34. Xu, Y., Khaw, N. R. B. J., & Li, Z.* Efficient epoxidation of alkenes with hydrogen peroxide, lactone, and lipase. Green Chemistry, 2009, 11, 2047-2051. Link

33. Wang, W., Xu, Y., Wang, D. I., & Li, Z.* Recyclable nanobiocatalyst for enantioselective sulfoxidation: facile fabrication and high performance of chloroperoxidase-coated magnetic nanoparticles with iron oxide core and polymer shell. Journal of the American Chemical Society, 2009, 131, 12892-12893. Link

32. Dai, S., & Li, Z.* Enzymatic Preparation of Novel Thermoplastic di-Block Copolyesters Containing Poly [(R)-3-hydroxybutyrate] and Poly (Caprolactone) Blocks via Ring-Opening Polymerization. Biomacromolecules, 2008, 9, 1883-1893. Link

31. Jia, X., Wang, Z., & Li, Z.* Preparation of (S)-2-, 3-, and 4-chlorostyrene oxides with the epoxide hydrolase from Sphingomonas sp. HXN-200. Tetrahedron: Asymmetry, 2008, 19, 407-415. Link

30. Li, Z.*, Held, M., Panke, S., Schmid, A., Mathys, R., & Witholt, B. Biocatalysis for Industrial Green Chemistry. in Methods and Reagents for Green Chemistry: An Introduction, ed. Tundo, P.; Perosa, A.; Zecchini, F., Hoboken, N. J.: John Wiley & Sons, Inc., 2007, 281-298. Link

29. Liu, Z., Michel, J., Wang, Z., Witholt, B., & Li, Z.* Enantioselective hydrolysis of styrene oxide with the epoxide hydrolase of Sphingomonas sp. HXN-200. Tetrahedron: Asymmetry, 2006, 17, 47-52. Link

28. Zhang, J., Witholt, B., & Li, Z.* Coupling of permeabilized microorganisms for efficient enantioselective reduction of ketone with cofactor recycling. Chemical Communication, 2006, (4), 398-400. Link

27. Zhang, J., Witholt, B., & Li, Z.* Efficient NADPH Recycling in Enantioselective Bioreduction of a Ketone with Permeabilized Cells of a Microorganism Containing a Ketoreductase and a Glucose 6-Phosphate Dehydrogenase. Advanced Synthesis & Catalysis, 2006, 348, 429-433. Link

26. van Beilen, J. B.*, Funhoff, E. G., van Loon, A., Just, A., Kaysser, L., Bouza, M., Holtackers, R., Rothlisberger, M., Li, Z., & Witholt, B. Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases. Applied and Environmental Microbiology, 2006, 72, 59-65. Link

25. Angerer, P. S., Studer, A., Witholt, B., & Li, Z.* Oxidative polymerization of a substituted phenol with ion-paired horseradish peroxidase in an organic solvent. Macromolecules, 2005 38, 6248-6250. Link

24. Chang, D., Zhang, J., Witholt, B., & Li, Z.* Chemical and enzymatic synthetic methods for asymmetric oxidation of the CC double bond. Biocatalysis and Biotransformation, 2004, 22, 113-131. Link

23. Zhang, J., Duetz, W. A., Witholt, B., & Li, Z.* Rapid identification of new bacterial alcohol dehydrogenases for (R)-and (S)-enantioselective reduction of beta-ketoesters. Chemical Communications, 2004, 18, 2120-2121. Link

22. Li, Z.*, & Chang, D. Recent advances in regio-and stereoselective biohydroxylation of non-activated carbon atoms. Current Organic Chemistry, 2004, 8, 1647-1658. Link

21. Li, Z.*, Butikofer, L., & Witholt, B. High-Throughput Measurement of the Enantiomeric Excess of Chiral Alcohols by Using Two Enzymes. Angewandte Chemie International Edition, 2004, 43, 1698-1702. Link

20. Van Beilen, J. B.*, Li, Z., Duetz, W. A., Smits, T. H., & Witholt, B. Diversity of alkane hydroxylase systems in the environment. Oil & gas science and technology, 2003 58, 427-440. Link

19. Chang, D., Heringa, M. F., Witholt, B., & Li, Z.* Enantioselective Trans Dihydroxylation of Nonactivated CC Double Bonds of Aliphatic Heterocycles with Sphingomonas sp. HXN-200. The Journal of Organic Chemistry, 2003, 68, 8599-8606. Link

18. Chang, D., Wang, Z., Heringa, M. F., Wirthner, R., Witholt, B., & Li, Z.* Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols. Chemical Communications, 2003, 960-961. Link

17. Andrade, A. P., Witholt, B., Chang, D., & Li, Z.* Synthesis and characterization of novel thermoplastic polyester containing blocks of poly [(R)-3-hydroxyoctanoate] and poly [(R)-3-hydroxybutyrate]. Macromolecules, 2003, 36, 9830-9835. Link

16. Van Beilen, J. B.*, Mourlane, F., Seeger, M. A., Kovac, J., Li, Z., Smits, T. H., Fritsche, U. & Witholt, B. Cloning of Baeyer-Villiger monooxygenases from Comamonas, Xanthobacter and Rhodococcus using polymerase chain reaction with highly degenerate primers. Environmental Microbiology, 2003 5, 174-182. Link

15. Chang, D., Feiten, H. J., Witholt, B., & Li, Z.* Regio-and stereoselective hydroxylation of N-substituted piperidin-2-ones with Sphingomonas sp. HXN-200. Tetrahedron: Asymmetry, 2002, 13, 2141-2147. Link

14. Andrade, A. P., Witholt, B., Hany, R., Egli, T., & Li, Z.* Preparation and characterization of enantiomerically pure telechelic diols from mcl-poly [(R)-3-hydroxyalkanoates]. Macromolecules, 2002, 35, 684-689. Link

13. Chang, D., Feiten, H. J., Engesser, K. H., van Beilen, J. B., Witholt, B., & Li, Z.* Practical syntheses of N-substituted 3-hydroxyazetidines and 4-hydroxypiperidines by hydroxylation with Sphingomonas sp. HXN-200. Organic Letters, 2002 4, 1859-1862. Link

12. Andrade, A. P., Neuenschwander, P., Hany, R., Egli, T., Witholt, B., & Li, Z. Synthesis and characterization of novel copoly (ester-urethane) containing blocks of poly-[(R)-3-hydroxyoctanoate] and poly-[(R)-3-hydroxybutyrate]. Macromolecules, 2002, 35, 4946-4950. Link

11. Li, Z.*, van Beilen, J. B., Duetz, W. A., Schmid, A., de Raadt, A., Griengl, H., & Witholt, B. Oxidative biotransformations using oxygenases. Current Opinion in Chemical Biology, 2002, 6, 136-144. Link

10. Beilen, J. B. V.*, & Li, Z. Enzyme technology: an overview. Current Opinion in Biotechnology, 2002, 13, 338-344. Link

9. Li, Z.*, Feiten, H. J., Chang, D., Duetz, W. A., van Beilen, J. B., & Witholt, B. Preparation of (R)-and (S)-N-protected 3-hydroxypyrrolidines by hydroxylation with Sphingomonas sp. HXN-200, a highly active, regio-and stereoselective, and easy to handle biocatalyst. The Journal of Organic Chemistry, 2001, 66, 8424-8430. Link

8. Chang, D., Witholt, B., & Li, Z.* Preparation of (S)-N-Substituted 4-Hydroxy-pyrrolidin-2-ones by Regio-and Stereoselective Hydroxylation with Sphingomonas sp. HXN-200. Organic Letters, 2000, 2, 3949-3952. Link

7. Li, Z.*, Feiten, H. J., van Beilen, J. B., Duetz, W., & Witholt, B. Preparation of optically active N-benzyl-3-hydroxypyrrolidine by enzymatic hydroxylation. Tetrahedron: Asymmetry, 1999, 10, 1323-1333. Link

6. Li, Z., & Undheim, K.* Selective Mono-and 1, 4-Di-/V-alkyiations of 1, 4, 7, 10-Tetraazacyclododecane. Acta Chemica Scandinavica, 1998, 52, 1247-1253. Link

5. Li, Z., & Vasella, A.* Synthesis of Enantiomerically Pure Carbohydrate-Derived Annulated Cyclopentadienes and Ferrocenes. Helvetica chimica acta, 1996, 79, 2201-2218. Link

4. Vedo, P., Chauvin, R., Li, Z., Bernet, B., & Vasella, A.* Synthesis of Enantiomerically Pure Ferrocenes from Glycofuranosyl-cyclopentadienes, synthetic equivalents of (alkoxyalkyl) fulvenes. Helvetica chimica acta, 1994, 77, 1631-1659. Link

3. Li, Z., & Schlogl, K.* Chiral crystals of meso-1, 1'-bi (9, 10-dihydro-9, 10-ethano-anthryl). Chiroptical properties, absolute chirality and rotational barrier. Monatshefte fur Chemie/Chemical Monthly, 1993, 124, 1211-1215. Link

2. Li, Z., Werner, A., & Schlogl, K.* Syntheses and absolute stereochemistry of chiral 9, 10-dihydro-9, 10-ethanoanthracenes and their tricarbonylchromium complexes. Monatshefte fur Chemie/Chemical Monthly, 1993, 124, 441-452. Link

1. Schlogl, K.*, Li, Z., & Kratky, C. Static and dynamic stereochemistry of 1, 1'-bi (9, 10-dihydro-9, 10-ethano-anthryl). Monatshefte fur Chemie/Chemical Monthly, 1991, 122, 1097-1108. Link